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Deflazacort

Deflazacort
Drug information
Systematic (IUPAC) name
IUPAC name(11β,16β)-21-(acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
Chemical data
Mol. mass441.517 g/mol
Protein binding40%
MetabolismBy plasma esterases, to active metabolite
Half-life1.1 � 1.9 hours (metabolite)
ExcretionRenal (70%) and fecal (30%)
Therapeutic considerations
RoutesOral

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Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It is sold in the United Kingdom by Shire under the trade name Calcort, in Brazil as Cortax, Decortil, and Deflanil, and in Honduras as Flezacor. It is not available in the United States.

Deflazacort is a prodrug. Its potency is around 70 � 90% that of prednisone.

Deflazacort Video


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Registra el ISSSTEP un grave desabasto de medicamentos: Aguilar Chedraui - La Jornada de Oriente Tweet this news
La Jornada de Oriente--En los almacenes de la farmacia del Hospital 5 de Mayo entre los medicamentos y soluciones que están escasos figuran: paracetamol, ketorolaco, montelokast sódico, -deflazacort-, fosfato de sodio, sulfato salbutamol, gemfibrozilo d - Date : Thu, 03 Mar 2011 10:56:03 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Corticosteroids for systemic use (H02)

MineralocorticoidsAldosterone - Fludrocortisone - Desoxycortone
GlucocorticoidsBetamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol
AnticorticosteroidsTrilostane



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