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Beclometasone dipropionate

Beclometasone dipropionate
Drug information
Systematic (IUPAC) name
IUPAC name(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Chemical data
Mol. mass521.042 g/mol
BioavailabilityConverted to beclometasone-17-monopropionate (17-BMP) during absorption
Protein binding87% of 17-BMP to albumin and transcortin
MetabolismBy esterase enzymes found in most tissues
Half-life2.8 hours
Excretion?
Therapeutic considerations
RoutesOral & nasal inhalation, topical

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Beclometasone dipropionate (INN modified) or beclomethasone dipropionate (USAN, former BAN), also referred to as beclometasone (INN), is a potent glucocorticoid steroid. In the form of an inhaler (e.g. Clenil, Qvar), a wide number of brands of which are available, it is used for the prophylaxis of asthma. As a nasal spray (e.g. Beconase, alanase, Vancenase), it is used for the treatment of rhinitis (e.g. hayfever) and sinusitis. In some instances, it is used by oral pathologists in the treatment of unusually severe aphthous ulcers.

As a cream or ointment (trade name Propaderm), it is used to treat severe inflammatory skin disorders (e.g. eczema) unresponsive to less potent steroids, but is generally avoided in the treatment of psoriasis due to the risk of rebound on withdrawal.

It is also licensed to treat ulcerative colitis in conjunction with doses of 5-aminosalicylates in the United Kingdom in the form of a gastric acid-resistant, periodic release tablet marketed under the brand name Clipper.

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소아 경증천식 응급치료에 ICS+SABA - 메디칼트리뷴 Tweet this news
메디칼트리뷴--연구팀은 응급치료법으로서 ICS(-beclomethasone dipropionate-, BDP)의 효과를 검토하기 위해 무작위 비교시험을 실시했다. 시험에는 5개 시설이 참가했다. 5~18세 경증지속형 천식환자를 (1 - Date : Tue, 08 Mar 2011 15:13:16 GMT+00:00
Teva Announces Results from a Phase III Study for QNAZE™ Nasal Aerosol in ... - Bradenton Herald Tweet this news
Bradenton Herald--Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) today announced results from a Phase III study of QNAZE™ (-beclomethasone dipropionate- [BDP]) HFA, its nasal aerosol corticosteroid in development for the treatment of perennial aller - Date : Wed, 09 Feb 2011 15:44:04 GMT+00:00
Corticosteroid Effective Asthma Rescue Addition - MD News (press release) Tweet this news
MD News (press release)--Fernando D. Martinez, MD, from the University of Arizona in Tucson, and colleagues examined the effectiveness of -beclomethasone dipropionate- as a rescue treatment in a 44-week trial involving 288 children aged 5 to 18 with mild - Date : Tue, 15 Feb 2011 19:43:55 GMT+00:00
Teva's phase III study of Qnaze nasal aerosol in perennial allergic rhinitis ... - pharmabiz.com Tweet this news
pharmabiz.com--Teva Pharmaceutical Industries Ltd. announced results from a phase III study of Qnaze (-beclomethasone dipropionate- [BDP]) HFA, its nasal aerosol corticosteroid in development for the treatment of perennial allergic rhinitis (PAR) and seas - Date : Fri, 11 Feb 2011 04:42:28 GMT+00:00
Rescue Therapy for Asthma May Help Avoid Daily Use of Corticosteroids - Medscape Tweet this news
Medscape--"We assessed the effectiveness of an inhaled corticosteroid (-beclomethasone dipropionate-) used as rescue treatment." Children and adolescents 5 to 18 years old with mild persistent asthma were enrolled from 5 clinical US cent - Date : Fri, 25 Feb 2011 18:05:18 GMT+00:00
Teva's Qnaze meets endpoints in phase-3 trial - Drug Store News Tweet this news
Drug Store News--Teva said the phase-3 trial of the nasally inhaled drug Qnaze (-beclomethasone dipropionate-) showed that it significantly relieved symptoms of seasonal and perennial allergic rhinitis compared with placebo while demonstrating a similar s - Date : Thu, 10 Feb 2011 15:57:10 GMT+00:00
Soligenix Inc names Kevin Horgan, MD chief medical officer - Trading Markets (press release) Tweet this news
Trading Markets (press release)---...- of its confirmatory Phase 3 clinical trial of orBec (oral -beclomethasone dipropionate- or BDP) in the treatment of acute gastrointestinal (GI) GVHD. ... - Date : Wed, 02 Feb 2011 12:20:06 GMT+00:00
Soligenix gets US FDA orphan drug status for RiVax for prevention of ricin ... - pharmabiz.com Tweet this news
pharmabiz.com--Soligenix's lead product, orBec (oral -beclomethasone dipropionate-), is a potent, locally acting corticosteroid being developed for the treatment of acute ... - Date : Mon, 24 Jan 2011 08:44:10 GMT+00:00
Product news - Dispensing Doctors' Association Tweet this news
Dispensing Doctors' Association--Allen & Hanburys' Becodisks 200 Micrograms and Becodisks 100 Micrograms (-beclometasone dipropionate-) now carry a shelf life of two years. ... - Date : Wed, 22 Dec 2010 00:16:09 GMT+00:00
Moderate vs Low ICS Doses May Not Give Added Benefit in Childhood Asthma - Medscape Tweet this news
Medscape--"The most recent asthma guidelines recommend a dose of up to 400 μg/day -beclomethasone dipropionate- (BDP)-hydrofluoroalkane equivalent for children with ... - Date : Wed, 08 Dec 2010 17:02:00 GMT+00:00

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids		Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants
Short acting β2-agonistsSalbutamol/Levosalbutamol * Fenoterol * Terbutaline * Pirbuterol * Procaterol * Bitolterol * Rimiterol * Carbuterol * Tulobuterol * Reproterol
Long acting β2-agonists (LABA)Arformoterol * Bambuterol * Clenbuterol * Formoterol * Salmeterol Ultra LABA: Indacaterol
otherEpinephrine * Hexoprenaline * Isoprenaline (Isoproterenol) * Orciprenaline (Metaproterenol)
Glucocorticoids
Beclometasone * Budesonide * Ciclesonide * Fluticasone * Mometasone
Anticholinergics/
muscarinic antagonist
Ipratropium * Tiotropium
Mast cell stabilizers
Cromoglicate * Nedocromil
Xanthines
Doxofylline * Theobromine * Theophylline/Aminophylline
Eicosanoid inhibition
Leukotriene antagonistsMontelukast * Pranlukast * Zafirlukast
Lipoxygenase inhibitorZileuton
Thromboxane receptor antagonistsRamatroban * Seratrodast
Combination products
Budesonide/formoterol * Fluticasone/salmeterol * Ipratropium/salbutamol |belowstyle=background:MistyRose

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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