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11-Deoxycorticosterone

11-Deoxycorticosterone
Drug information
Systematic (IUPAC) name
IUPAC name(1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
Chemical data
Mol. mass330.461

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11-Deoxycorticosterone (or deoxycorticosterone or 21-hydroxyprogesterone) is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. As its names indicate, it can be understood as 21-hydroxy- variant of progesterone or a 11-deoxy- variant of corticosterone. It has no significant glucocorticoid activity.

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Evolution of ligand specificity in vertebrate corticosteroid receptors - 7thSpace Interactive (press release) Tweet this news
7thSpace Interactive (press release)--Results: We used up to seven steroids (including aldosterone, cortisol and -11-deoxycorticosterone- [DOC]) to compare the ligand specificity of the ligand ... - Date : Fri, 14 Jan 2011 10:56:12 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Cholesterol and steroid metabolic intermediates

General
|Mevalonate pathway |
Non-mevalonate pathway
DOXP * MEP * CDP-ME * CDP-MEP * MEcPP * HMB-PP * IPP * DMAPP
To Cholesterol
Farnesyl pyrophosphate * Squalene * 2,3-Oxidosqualene * Lanosterol Lanosterol * Lathosterol * 7-Dehydrocholesterol * Cholesterol Lanosterol * Zymosterol * 7-Dehydrodesmosterol * Desmosterol * Cholesterol
Steroid

Cholesterol and steroid metabolic intermediates

General
|Mevalonate pathway |
Non-mevalonate pathway
DOXP * MEP * CDP-ME * CDP-MEP * MEcPP * HMB-PP * IPP * DMAPP
To Cholesterol
Farnesyl pyrophosphate * Squalene * 2,3-Oxidosqualene * Lanosterol Lanosterol * Lathosterol * 7-Dehydrocholesterol * Cholesterol Lanosterol * Zymosterol * 7-Dehydrodesmosterol * Desmosterol * Cholesterol
Steroid
General
|Mevalonate pathway |
Non-mevalonate pathway
DOXP * MEP * CDP-ME * CDP-MEP * MEcPP * HMB-PP * IPP * DMAPP
To Cholesterol
Farnesyl pyrophosphate * Squalene * 2,3-Oxidosqualene * Lanosterol Lanosterol * Lathosterol * 7-Dehydrocholesterol * Cholesterol Lanosterol * Zymosterol * 7-Dehydrodesmosterol * Desmosterol * Cholesterol
Steroid
subgroup |groupstyle= |liststyle= |Corticosteroids
(C21 pregnane) |
MineralocorticoidsPregnenolone * Progesterone * 11-Deoxycorticosterone * Corticosterone * Aldosterone
GlucocorticoidsPregnenolone * 17-Hydroxypregnenolone * 17-Hydroxyprogesterone * 11-Deoxycortisol * Cortisol
Cortisol * Cortisone
Sex steroids
Androgens
(C19 androstane)
DHEA * Androstenedione/5-Androstenediol * Testosterone * Dihydrotestosterone
DHEA sulfate * Epitestosterone
Estrogens
(C18 estrane)
Estrone * Estradiol * Estriol



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