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Flunisolide

Flunisolide
Drug information
Systematic (IUPAC) name
IUPAC name(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Chemical data
Mol. mass434.498 g/mol
Synonyms6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal
Protein binding40% after oral inhalation
Half-life1.8 hours
Therapeutic considerations
RoutesInhaled

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Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid often prescribed as treatment for allergic rhinitis.

The principal mechanism of action of flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.

Category:Glucocorticoids

Category:Organofluorides

it:Flunisolide

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RIMEDI PER L'ALLERGIA AI POLLINI: I CORTICOSTEROIDI - Infosalute Tweet this news
Infosalute--Ne sono degli esempi: il fluticasone (Avamys®, Flixonase®), il mometasone (Nasonex®), il budesonide (Aircort®, Kesol®, Eltair®), il -flunisolide- (Lunis®, Nisolid®), il triamcinolone (Nasacort®) e il beclometasone (Becotide®, Rinocle - Date : Tue, 27 Mar 2012 22:06:12 GMT
흡입스테로이드 사용 COPD환자 사망위험 20% 이상↓ - 메디칼트리뷴 Tweet this news
메디칼트리뷴--트리암시놀론, 플루티카손, 부데소나이드, 베클로메타손, 플루니솔라이드(-flunisolide-)를 입원하기 전 90일 이내에 처방받아 ICS를 사용한 사람은 8271명(52.5%), 비사용자는 7497명(47.5% - Date : Thu, 21 Apr 2011 22:07:39 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids		Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants
Short acting β2-agonistsSalbutamol/Levosalbutamol * Fenoterol * Terbutaline * Pirbuterol * Procaterol * Bitolterol * Rimiterol * Carbuterol * Tulobuterol * Reproterol
Long acting β2-agonists (LABA)Arformoterol * Bambuterol * Clenbuterol * Formoterol * Salmeterol Ultra LABA: Indacaterol
otherEpinephrine * Hexoprenaline * Isoprenaline (Isoproterenol) * Orciprenaline (Metaproterenol)
Glucocorticoids
Beclometasone * Budesonide * Ciclesonide * Fluticasone * Mometasone
Anticholinergics/
muscarinic antagonist
Ipratropium * Tiotropium
Mast cell stabilizers
Cromoglicate * Nedocromil
Xanthines
Doxofylline * Theobromine * Theophylline/Aminophylline
Eicosanoid inhibition
Leukotriene antagonistsMontelukast * Pranlukast * Zafirlukast
Lipoxygenase inhibitorZileuton
Thromboxane receptor antagonistsRamatroban * Seratrodast
Combination products
Budesonide/formoterol * Fluticasone/salmeterol * Ipratropium/salbutamol |belowstyle=background:MistyRose



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