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Fluticasone furoate

Fluticasone furoate
Drug information
Systematic (IUPAC) name
IUPAC name(6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furancarboxylate
Chemical data
Mol. mass538.576 g/mol
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Hepatic (CYP3A4-mediated)
Half-life10 hours
ExcretionRenal
Therapeutic considerations
Pregnancy cat C for Intranasal
RoutesIntranasal

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Fluticasone furoate is a synthetic corticosteroid derived from fluticasone, marketed by GlaxoSmithKline as Veramyst (US) and Avamys (Australia, Canada, EU, South Africa and Mexico) for the treatment of allergic rhinitis. It is marketed under the name "Furamist" in India by Cipla.

It can be administered by a nasal spray.



Fluticasone furoate Video

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Theravance, GlaxoSmithKline achieve mixed results from Relovair phase 3 studies - Proactive Investors USA & Canada Tweet this news
Proactive Investors USA & Canada--Patients received either a once-daily, 100/25 microgram (mcg) dose of Relovair, which is comprised of -fluticasone furoate- and vilanterol (FFVI), an inhaled corticosteroid, or a twice-daily 250/50 mcg dose of Advair, - Date : Fri, 23 Mar 2012 19:23:08 GMT
GlaxoSmithKline ups stake in COPD drug partner Theravance - The Pharma Letter Tweet this news
The Pharma Letter--The news follows the recent announcement that the registrational program for their investigational drug Relovair (-fluticasone furoate- and vilanterol (FF/VI) is now complete (The Pharma Letter March 26). For chronic obstructive pulmona - Date : Tue, 03 Apr 2012 09:22:48 GMT
Canadian Generic Pharmaceutical Association v. Canada (Minister of Health) and ... - Lexology (registration) Tweet this news
Lexology (registration)--This appeal affirmed two lower decisions (2011 FC 465 and 2010 FC 1211) where it was held that the CGPA lacked standing to bring the application to dispute the listing of -fluticasone furoate- on the Patent Register on the basis t - Date : Tue, 24 Jan 2012 10:18:18 GMT
Glaxo and Theravance Suffer Setback - Zacks.com Tweet this news
Zacks.com--Relovair is a combination of -fluticasone furoate- and vilanterol. In the two COPD studies, Relovair reduced the annual rate of moderate-to-severe exacerbations (worsening of severity of disease) compared to vilanterol. However, in the second s - Date : Thu, 12 Jan 2012 22:16:23 GMT
Morning Movers 01/09: (INHX) (IDIX) (SMSI) (CVV) (VVUS) Higher; (THRX) (IPCM ... - StreetInsider.com (subscription) Tweet this news
StreetInsider.com (subscription)--Theravance, Inc. (Nasdaq: THRX) 31.7% LOWER; GlaxoSmithKline (NYSE: GSK) and Theravance today announced the completion of the phase III registration programme for the once-daily investigational medicine Relovair" - Date : Mon, 09 Jan 2012 16:21:04 GMT
GlaxoSmithKline завершила испытания III фазы по препарату Relovair - Азиатский репортер Tweet this news
Азиатский репортер--GlaxoSmithKline PLC и Theravance Inc. объявили в понедельник о завершении испытаний III фазы препарата Relovair (-fluticasone furoate-/vilanterol), в ходе ко - Date : Mon, 09 Jan 2012 09:52:39 GMT
复方Relovair治疗COPD III期研究结果积极 - 生物谷 Tweet this news
生物谷--Relovair为一日一次的吸入型皮质类固醇(ICS)和长效β2-受体激动剂(LABA)的复方治疗药物(FF/VI),即糠酸氟替卡松(-Fluticasone Furoate-,FF)和维兰特罗(Vilanterol,VI),目前该药正处� - Date : Wed, 08 Jun 2011 02:57:03 GMT+00:00
GlaxoSmithKline Reports Results Of Phase III Studies Of Relovair - Wall Street Journal Tweet this news
Wall Street Journal---Relovair is a once-daily inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA) combination treatment, comprising -fluticasone furoate- and vilanterol (FF/VI), currently under development for the treatment of COPD and asthma. . - Date : Thu, 02 Jun 2011 11:31:27 GMT+00:00
Glaxo's asthma market lead to run out of puff - Australian Life Scientist Tweet this news
Australian Life Scientist--Later this year Glaxo is expected to launch in Australia its new once-daily Relovair (-fluticasone furoate-/vilanterol) asthma treatment product. ... - Date : Mon, 24 May 2010 21:59:21 GMT+00:00

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids
Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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