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Methylprednisolone

Methylprednisolone
Drug information
Systematic (IUPAC) name
IUPAC name(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Chemical data
Mol. mass374.471 g/mol
Synonyms(6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione
Protein binding78%
Metabolismliver primarily, kidney, tissues; CYP450: 3A4 substrate
Half-lifeurine; Half-life: 18-26h (biological)
Therapeutic considerations
RoutesIV, IM, IV Infusion, Oral, Rectal, Topical

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Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol. It is also available as a generic drug.

It is a variant of prednisolone, methylated at carbon 6 of the B ring.

Methylprednisolone Video

Animal prescription medications are available through Drs. Foster and Smith's Free-Shipping Pharmacy. Foster & Smith, Inc. is fully licensed in all 50 states. This medication can be ordered at www.drsfostersmith.com
2.12 min. | 5.0 user rating
canadianselect.org - convert iv methylprednisolone to po prednisone
0.17 min. | 1.0 user rating
80mg Dosage of Methylprednisolone over to course of year to treat severe Lupus flare. For more information please visit our site LissasWorld.com: bit.ly Follow Us on Twitter: bit.ly Follow Lissa on Twitter: bit.ly Follow us on Facebook:on.fb.me
2.15 min. | 5.0 user rating
I'm in a relapse...so that means more meds... So currently I am taking: Gebapentin, Methylprednisolone, some crazy antacid, beta-interferon, vitamin D supplements, vitamin B complex, cerazette... Hopefully the steroids will make the relapse shorter. For more information on what a relapse is, see here: heidelscorner.blogspot.com
11.08 min. | 0 user rating
Spinal Cord Injury, the Golden Hour, Cervical Collar, Solumedrol, Fall prevention, the Braden Scale
4.98 min. | 5.0 user rating
Our transfer trip to NYC
5.73 min. | 5.0 user rating
Dr. Kantor is the neurologist on board the MSF (MS Foundation) Cruise For A Cause -- It's all about MEE -- Motivating * Educating * Empowering. Hear an introduction to the topics discussed on this patient (and carepartner) educational cruise to the Western Caribbean. Next year (2013), the cruise will be in Alaska -- email: cruise@msfocus.org
1.68 min. | 0 user rating
Just how many babies are on board? If you wanna guess, here are my numbers: 6days past 5 day transfer = 37.1 11dp = 162 13dp = 379 18dp = 2500 20 dp = 3702...then I stopped keeping track. ;-) to visit my agency, go to www.reproductivepossibilities.com I also want to welcome all surrogates or potential surrogates to visit http This is an online chat forum on BabyZone.com for surrogates
0.40 min. | 5.0 user rating
Dr. Kantor is the neurologist on board the MSF (MS Foundation) Cruise For A Cause -- It's all about MEE -- Motivating * Educating * Empowering. Hear a summary to the topics discussed on this patient (and carepartner) educational cruise to the Western Caribbean. Next year (2013), the cruise will be in Alaska -- email: cruise@msfocus.org
7.28 min. | 0 user rating
The transfer results!! Sorry this took so long for me to upload today. I just realized that I spent 2 HOURS editing! Wowza! Originally 16 minutes long, then it got kicked for being too long, so I had to go back and edit MORE out, which is why it's kinda choppy in places. Guess I had a lot to say! to visit my agency, go to www.reproductivepossibilities.com I also want to welcome all surrogates or potential surrogates to visit http This is an online chat forum on BabyZone.com for surrogates
14.63 min. | 5.0 user rating

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InVivo Therapeutics Reports First Quarter 2011 Financial Results - Business Wire (press release) Tweet this news
Business Wire (press release)--“An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of -methylprednisolone- sodium succinate for treatment of spinal cord injury and in neurosurgical applications.” For the three months end - Date : Mon, 16 May 2011 10:27:49 GMT+00:00
Acute Spinal Cord Injury (ASCI) Therapeutics - Pipeline Assessment and Market ... - PRLog.Org (press release) Tweet this news
PRLog.Org (press release)--Medrol (-methylprednisolone-), which helps to educe swelling in the spinal cord, is widely prescribed as an off-label drug. However, it is unable to ompletely serve the market's unmet needs. The absence of effective treatme - Date : Mon, 30 May 2011 06:48:47 GMT+00:00
Injection therapy for sudden hearing loss disorder may be suitable alternative ... - The Virtual Medical Centre Tweet this news
The Virtual Medical Centre--The current standard treatment for idiopathic hearing loss has been a course of oral corticosteroid (prednisone or -methylprednisolone-), according to background information in the article. In recent years, intratympanic (withi - Date : Sun, 29 May 2011 14:02:33 GMT+00:00
Oral vs Intratympanic Corticosteroid Therapy for Idiopathic Sudden ... - Journal of American Medical Association (subscription) Tweet this news
Journal of American Medical Association (subscription)--Intervention One hundred twenty-one patients received either 60 mg/d of oral prednisone for 14 days with a 5-day taper and 129 patients received 4 doses over 14 days of 40 mg/mL of -methylprednisolon - Date : Tue, 24 May 2011 20:37:24 GMT+00:00
Acute Respiratory Distress Syndrome (ARDS) Therapeutics - Pipeline Assessment ... - PRLog.Org (press release) Tweet this news
PRLog.Org (press release)--Treatment currently relies on off-label drugs such as Levaquin -methylprednisolone-. The market subsequently needs therapies offering better results in terms of safety treatment of ARDS. The market is dominated by off-label trea - Date : Tue, 07 Jun 2011 04:49:20 GMT+00:00
InVivo touts experimental hydrogel for spinal cord injuries - Mass Device Tweet this news
Mass Device--The technology, designed to address the underlying pathology of SCI, is intended for "sustained release of -methylprednisolone- sodium succinate," according to InVivo. The company designed its latest research on the hydrogel - Date : Thu, 10 Mar 2011 00:39:36 GMT+00:00
Sonographically Guided Corticosteroid Injection for Treatment of Plantar Fasciosis - Journal of Ultrasound in Medicine (subscription) Tweet this news
Journal of Ultrasound in Medicine (subscription)--Two milliliters (20 mg/mL) of lignocaine/prilocaine, 1%, and 0.5 mL (20 mg) of -methylprednisolone- acetate solutions were injected separately. The plantar fascia and fat pad thickness, fascial echogenicit - Date : Fri, 01 Apr 2011 16:45:31 GMT+00:00
Corticosteroids in Cardiopulmonary Bypass Surgery - AAP Grand Rounds (registration) Tweet this news
AAP Grand Rounds (registration)---Methylprednisolone- was the most commonly used CS (70%) followed by dexamethasone (27%). CS was received by 79% on the day of surgery and 12% on both the day prior and the day of surgery. Overall, there was no difference - Date : Fri, 01 Apr 2011 15:17:27 GMT+00:00
Surgeon Scott Spann faced a long road to recovery following cycling accident - Austin 360 Tweet this news
Austin 360--On his way to the emergency room, he asked to be given -methylprednisolone-, a sometimes controversial treatment of steroids that must be injected within four hours to minimize inflammation in the spinal cord. Spann had injured the second thro - Date : Mon, 07 Mar 2011 17:01:21 GMT+00:00
2 drugs protect hearing better than 1 - EurekAlert (press release) Tweet this news
EurekAlert (press release)--And two of the drugs in combination, the anticonvulsant zonisamide and the glucocorticoid -methylprednisolone-, showed comparable hearing protection at much lower doses than when administered alone. While the drugs do not preve - Date : Wed, 23 Feb 2011 16:36:47 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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