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Mometasone furoate

Drug information
Systematic (IUPAC) name
IUPAC name(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Chemical data
FormulaC22H28Cl2O4forMometasone
C27H30O6Cl2asFuroate
Mol. mass427.361 g/mol (Mometasone)
521.4 g/mol (Furoate)
Synonyms(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
BioavailabilityNasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.
Protein binding98% to 99%
Metabolismhepatic
Half-life5.8 hours
Therapeutic considerations
Legal status Rx Only (US)
Routestopical, nasal

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Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.

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Mometasone Furoate Reduces Ocular Allergy Symptoms - MD News (press release) Tweet this news
MD News (press release)---Mometasone furoate- nasal spray and other intranasal corticosteroids reduce ocular symptoms in patients with seasonal allergic rhinitis and perennial allergic rhinitis, according to a meta-analysis published online Jan. 25 in All - Date : Thu, 17 Feb 2011 14:54:41 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids		Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose



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