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Metyrapone

Metyrapone
Drug information
Systematic (IUPAC) name
IUPAC name2-methyl-1,2-di(pyridin-3-yl)propan-1-one
Chemical data
Mol. mass226.274 g/mol
Half-life1.9 ±0.7 hours.
Therapeutic considerations
Pregnancy cat C US
RoutesOral

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Metyrapone (trade name Metopirone) is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism).

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Embera NeuroTherapeutics and Collaborators Publish Paper in Psychopharmacology ... - MarketWatch (press release) Tweet this news
MarketWatch (press release)---Metyrapone- and oxazepam, both of which are FDA-approved drugs, comprise EMB-001, Embera's lead pipeline candidate. Researchers found that at the lowest doses tested, the combination more effectively reduced nicotine int - Date : Fri, 16 Mar 2012 13:01:10 GMT
Drug may reduce emotional impact of bad memories - Blacktown Sun Tweet this news
Blacktown Sun--University of Montreal researchers are beginning to believe so after they found that the drug -metyrapone- reduced the brain's ability to re-record the negative emotions associated with painful memories. The team of researchers said th - Date : Tue, 07 Jun 2011 18:31:30 GMT+00:00
In The News - The Sudbury Star Tweet this news
The Sudbury Star--The drug, -metyrapone-, blocks the stress hormone cortisol and the study found that a certain dosage caused participants to remember significantly less significantly less of the negative emotional components negative emotional components - Date : Thu, 02 Jun 2011 10:30:24 GMT+00:00
The Heat And Mavericks In Game 2, Our Best Chance At An NBA Finals Classic - SB Nation Tweet this news
SB Nation--Okay, so this sounds more like the future: University of Montreal researchers say that the drug -metyrapone- reduces the brain's ability to re-record the negative emotions associated with painful memories. In other words, bad memories are - Date : Thu, 02 Jun 2011 20:48:26 GMT+00:00
Drug metyrapone may help overwrite bad memories - HealthJockey.com Tweet this news
HealthJockey.com--According to the investigators the drug -metyrapone- appears to prominently reduce the levels of a stress hormone that is associated with memory recall known as cortisol. The negative emotions related to any new thought popping into the - Date : Mon, 30 May 2011 09:17:21 GMT+00:00
Tragara releases Apricoxib results; Metyrapone shows promise for PTSD treatment; - FierceBiotech Tweet this news
FierceBiotech--Tragara release > A cortisone-blocking drug, -metyrapone-, offers potential line of attack against post-traumatic stress disorder. Article > Exton, PA-based Nuron Biotech will use PolyTheric's TheraPEG technology on NU400 - Date : Fri, 27 May 2011 14:54:09 GMT+00:00
Happy pill to wipe out bad memories - The Sun Tweet this news
The Sun--The drug, -metyrapone-, has been around for decades but is no longer available. It was once used to treat hormone disorders and lowers the level of a brain chemical linked to memory recall. Scientists from Canada's Montreal University decide - Date : Fri, 27 May 2011 03:30:49 GMT+00:00

Diagnostic agents (V04)

Digestive system
DiabetesTolbutamide * Glucose
Fat absorptionVitamin A concentrates
Bile duct patencySorbitol * Magnesium sulfate * Sincalide * Ceruletide
Liver functional capacityGalactose * Sulfobromophthalein
Gastric secretionCation exchange resins * Betazole * Histamine phosphate * Pentagastrin * Methylthioninium chloride * Caffeine and sodium benzoate
Exocrine pancreatic functionSecretin * Pancreozymin (cholecystokinin) * Bentiromide
Endocrine system
Pituitary functioncortisol: Metyrapone * Corticorelin
GH: Sermorelin * Somatorelin
Thyroid functionThyrotropin * Protirelin
Fertility disturbancesGonadorelin
Tuberculosis
Tuberculin |Renal function |Inulin and other polyfructosans * Indigo carmine * Phenolsulfonphthalein * Alsactide * Aminohippuric acid
Renal function
Inulin and other polyfructosans * Indigo carmine * Phenolsulfonphthalein * Alsactide * Aminohippuric acid

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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