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Dexamethasone

Dexamethasone
Drug information
Systematic (IUPAC) name
IUPAC name(8S,9R,10S,11S,13S,14S,16R,17R)-9- Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16- trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Chemical data
Mol. mass392.461 g/mol
Bioavailability80-90%
Protein binding70%
Metabolismhepatic
Half-life36-54 hours
Excretionrenal
Therapeutic considerations
Legal status Rx-only
RoutesOral, IV, IM, SC and IO

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Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. It is 20 to 30 times more potent than the naturally occurring hormone cortisol and 4 to 5 times more potent than prednisone.

Dexamethasone Video

This video shows you intratympanic drug delivery to the inner ear. Our protocol takes place in the outpatient clinic under mi-croscopic control. The patient lies flat on a stretcher in the office with the neck fully extended and the head turned 45 degrees to the opposite side. We use Emla cream (Lidocaine 2.5%/Prilocaine 2.5%, Astra Zeneca Pharmaceuticals, LP, Wilmington, DE) to regionally anesthetize the tympanic membrane in the quadrant anterosuperior of the involved ear. Either the dexamethasone solution, gentamicine or hydrogel are loaded into a 3-mL syringe on which is placed a 22-gauge needle. The tip of the needle is angled. Filling the middle ear with a simple needle injection was not difficult. After the injection was administered slowly, the patient was instructed to lie in the supine position with the treated ear up for one hour, to keep their head still, and to swallow as little as possible, with no talking. Subsequent injections were delivered in the same way each day for the next 4 days. After each day's procedure the patient returned to his or her normal daily activities.
2.45 min. | 5.0 user rating		 Always hungry! One of the major side effects is an increased appetite and weight gain. I love food though. Please subscribe to the 5WW: www.youtube.comDISCLAIMER: I'm not a doctor or medical professional. Please consult your doctor if you have any concerns and before taking any medication. All audio, artwork, and graphics are royalty free content created using the Corel Video Studio Pro X3 software.
3.57 min. | 5.0 user rating		 Cushing's disease and the dexamethasone suppression test are one of those concepts that medical students cannot seem to keep straight. In this video I am going to simply it so that when you encounter a questions about it on the Step 1 exam you'll be ready. www.usmlesuccess.net
12.75 min. | 4.85 user rating		 Dr. Vincent Rajkimar provides an update on a trial of Revlimid with dexamethasone in multiple myeloma at the 2007 ASCO meeting. This trial concluded that lower doses of dex produced superior results. For more information, contact the International Myeloma Foundation, www.myeloma.org, theimf@myeloma.org, 800-452-2873 or 818-487-7455
4.08 min. | 0 user rating		 Glucocorticoids - Hydrocortisone, Prednisone, Triamcinolone, Dexamethasone, Beclomethasone, Iatrogenic Cushing's - First Aid for the USMLE Step 1, 2011 edition, Endocrine - Acclaim Reviews
2.23 min. | 3.66 user rating
Cushings Syndrome, Ectopic ACTH, Dexamethasone Test, Cushings Disease, High Cortisol - First Aid for the USMLE Step 1, 2011 edition, Endocrine - Acclaim Reviews www.AcclaimReviews.com
3.72 min. | 1.0 user rating		 Animal prescription medications are available through Drs. Foster and Smith's Free-Shipping Pharmacy at prices lower than your vet for the exact same product. We'll call to get the prescription for you, and ship it out FREE. Drs. Foster and Smith Inc. is fully licensed in all 50 states. This medication can be ordered at www.drsfostersmith.com
1.97 min. | 0 user rating		 Just a small refresher on Hyperandrogenism and the medication Dexamethasone.DISCLAIMER The participants in 5WaitingWombs are not medical professionals and do not take legal responsibility for any information or advice that is shared via videos, emails, comments. The information and facts we share are for educational purposes only and cannot substitute for a conversation with your doctor or pharmacist. We strongly encourage you to discuss with and obtain permission from your doctor before making any medical decision or beginning any over-the-counter or doctor prescribed drug(s) / herb(s).
5.23 min. | 5.0 user rating		 Here is my video update. My doctor prescribed me dexamethasone to lower my androgen levels. I'm nervous to start the medication but I'm hopeful that it will help me greatly. It's been a very busy week and I'm sorry I haven't updated sooner. Lost of baby dust to all of you! PS I love my HOPE necklace! It has lots of meaning. Special Thanks ;) Until next time!DISCLAIMER: I'm not a doctor or medical professional. Please consult your doctor if you have any concerns and before taking any medication. All audio, artwork, and graphics are royalty free content created using the Corel Video Studio Pro X3 software.
5.10 min. | 5.0 user rating		 Dr. Ruben Niesvizky discusses potential role of renal insuffieciciency in patients treated with the Biaxin Revlimid and Dexamethasone (BIRD) protocol multiple myeloma at the 2006 ASH meeting. For more information, contact the International Myeloma Foundation, www.myeloma.org, theimf@myeloma.org, 800-452-2873 or 818-487-7455
4.45 min. | 0 user rating

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American Regent recalls Dexamethasone Sodium Phosphate Injection and Sodium ... - ModernMedicine Tweet this news
ModernMedicine--American Regent, a division of Luitpold Pharmaceuticals in Shirley, NY, recently recalled several lots of -Dexamethasone- Sodium Phosphate Injection and Sodium Chloride Injection because they may contain particulates. -Dexamethasone- Sodiu - Date : Mon, 28 Mar 2011 18:50:11 GMT+00:00
American Regent Initiates Voluntary Nationwide Recall of Dexamethasone Sodium ... - FDA.gov Tweet this news
FDA.gov--PLEASE NOTE: This voluntary recall, initiated on March 16, 2011 to the User Level, is for ALL unexpired lots of all 3 sizes of -Dexamethasone- Sodium Phosphate Injection, USP. See attached Appendix for Lot #s, Expiration Dates and Dates of First - Date : Fri, 18 Mar 2011 03:34:52 GMT+00:00
American Regent Expands One Recall, Adds Another - MedPage Today Tweet this news
MedPage Today--A limited recall of injectable -dexamethasone- sodium phosphate has been expanded to include all unexpired lots, American Regent announced, and the company has also initiated a recall of seven lots of ... - Date : Thu, 17 Mar 2011 17:07:06 GMT+00:00
NCCN Modifies Guidelines For Multiple Myeloma - The Myeloma Beacon Tweet this news
The Myeloma Beacon--Both are combinations of cyclophosphamide and -dexamethasone- with either Velcade or Revlimid. The NCCN also changed a few recommendations regarding initial diagnostic workup. The NCCN added serum free light chain (FLC) assay to its re - Date : Mon, 21 Mar 2011 22:06:21 GMT+00:00
Adulterated Traditional Medicine & Cosmetic Products - Bru Direct Tweet this news
Bru Direct---...- was found to be adulterated with Sibutramine; Anna Sin Gang San Langsing Ayu, marketed in red and green packaging, are also adulterated with Sibutramine; and Majun Dua Istimewa, marketed as 'Asli' and 'Extra', is adul - Date : Sun, 13 Mar 2011 00:48:06 GMT+00:00
Chemotherapy Regimen Without High-Dose Dexamethasone Reduces Infections In ... - The Myeloma Beacon Tweet this news
The Myeloma Beacon--The results of a recent Japanese study suggest that a vincristine-doxorubicin--dexamethasone- regimen without intermittent high-dose -dexamethasone- reduces the ... - Date : Wed, 26 Jan 2011 17:27:08 GMT+00:00
Korean Botanical Limits Osteoporosis - Natural Products INSIDER Tweet this news
Natural Products INSIDER--The hexane extract of P. trifoliate inhibited apoptotic cell death in -dexamethasone--induced osteoblastic cell lines, C3H10T1/2 and MC3T3-E1. ... - Date : Fri, 28 Jan 2011 20:32:34 GMT+00:00
Thalidomide-Velcade Combination Without Steroids Is Effective For Newly ... - The Myeloma Beacon Tweet this news
The Myeloma Beacon--The novel agents are often used in combination with corticosteroids, such as -dexamethasone- (Decadron) and prednisone. Research has shown that, ... - Date : Fri, 28 Jan 2011 20:47:47 GMT+00:00
DON'T ASK ME: How much is that dexamethasone in the window? - Twin Falls Times-News Tweet this news
Twin Falls Times-News--If I don't buy expensive brand-name prescription drugs � you know, Lipitor, Nexium, Plavex, etc. � my insurer pays the bill. Otherwise, that'll be $185 ... - Date : Sun, 23 Jan 2011 08:15:32 GMT+00:00
AAO-HNS Issues New Clinical Guideline for Tonsillectomy in Children - Becker's ASC Review Tweet this news
Becker's ASC Review--The guidelines also identify other cases when children may still benefit from tonsillectomy, and provide guidance on the appropriate use of -dexamethasone- ... - Date : Fri, 28 Jan 2011 13:57:50 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Stomatological preparations (A01)

Caries prophylactic agentsOlaflur * Sodium fluoride * Sodium monofluorophosphate * Stannous fluoride
Anti-infectives and antisepticsAmphotericin B * Benzoxonium chloride * Chlorhexidine * Chlortetracycline * Clotrimazole * Domiphen * Doxycycline * Eugenol * Hexetidine * Hydrogen peroxide * Mepartricin * Metronidazole * Miconazole * Minocycline * Natamycin * Neomycin * Oxyquinoline * Polynoxylin * Sodium perborate * Tetracycline * Tibezonium iodide
Corticosteroids (Glucocorticoids)Dexamethasone * Hydrocortisone * Triamcinolone
OtherAmlexanox * Acetylsalicylic acid * Becaplermin * Benzydamine * Epinephrine/Adrenalone

Vasoprotectives (C05)

Antihemorrhoidals for topical usecorticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) other (Tribenoside)
Antivaricose therapyheparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) other (Calcium dobesilate)
Capillary stabilising agentsbioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

Corticosteroids for systemic use (H02)

MineralocorticoidsAldosterone - Fludrocortisone - Desoxycortone
GlucocorticoidsBetamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol
AnticorticosteroidsTrilostane

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids		Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose

Otologicals (S02)

Anti-infectivesAcetic acid * Aluminium acetotartrate * Boric acid * Chloramphenicol * Chlorhexidine * Ciprofloxacin * Clioquinol * Gentamicin * Hydrogen peroxide * Miconazole * Neomycin * Nitrofurazone * Ofloxacin * Polymyxin B * Rifamycin * Tetracycline
CorticosteroidsBetamethasone * Dexamethasone * Fluocinolone acetonide * Hydrocortisone * Prednisolone
Analgesics and anestheticsLidocaine * Cocaine * Phenazone



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