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Difluprednate

Difluprednate
Drug information
Systematic (IUPAC) name
IUPAC name[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
Chemical data
Mol. mass508.551
Therapeutic considerations
Routestopical dermatologic

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Difluprednate is a corticosteroid, a derivative of prednisolone obtained by fluorination at the 6- and 9-positions, followed by esterification of the 17 and 21-hydroxyl groups with butyric acid and acetic acid, respectively (see figure). Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate.

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Durezol And Durasal, Don't Get Them Mixed Up, FDA Warns - Medical News Today Tweet this news
Medical News Today--Eye drug Durezol (-difluprednate- ophthalmic emulsion) and wart remover Durasal (salicylic acid) may sound similar, but getting them mixed up can happen, and with potentially serious consequences, the Food and Drug Administration has w - Date : Fri, 30 Dec 2011 02:05:12 GMT
Similar product names cause confusion - ModernMedicine Tweet this news
ModernMedicine--Silver Spring, MD�The FDA is alerting pharmacists and other health-care professionals of potential injury due to confusion between the brand names of an agency-approved eye medication, -difluprednate- ophthalmic emulsion 0.05% (Durezol, .. - Date : Tue, 03 Jan 2012 23:23:25 GMT
News in Brief: Week of Jan. 2-6 - AAFP News Now Tweet this news
AAFP News Now--By News Staff The FDA is alerting pharmacists and other health care professionals of a potential for injury due to confusion between an FDA-approved eye medication -- -difluprednate- ophthalmic emulsion, which is sold as Durezol -- and the - Date : Fri, 06 Jan 2012 01:07:01 GMT

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)		HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)		Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)		Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)		Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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