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Fluticasone

Fluticasone
Drug information
Systematic (IUPAC) name
IUPAC nameS-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-
6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-
6,7,8,11,12,14,15,16-octahydrocyclopenta[a]
phenanthrene-17-carbothioate
Chemical data
Mol. mass444.508 g/mol
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Hepatic (CYP3A4-mediated)
Half-life10 hours
ExcretionRenal
Therapeutic considerations
Pregnancy cat C for Intranasal and Inhaled
RoutesIntranasal, Inhaled, Topical Cream or Ointment

     Home | Drugs | Fluticasone





Fluticasone is a synthetic glucocorticoid.

Both the furoate and propionate forms are used as topical anti-inflammatories:

*Fluticasone propionate

*Fluticasone furoate



Fluticasone Video

This is what it looks like when a cat has asthma. It looks like a cat trying to hack up a hair ball but no hair ball is ever produced. Our cat had it at an early age but his hacking episodes were not frequent in the beginning. The older he got, the more frequent his episodes became. He was hacking throughout the day and Vet tried X-Rays, blood tests and Hair Ball medicine. We went to the specialist and suggested to him also that it could possibly be feline asthma. The specialist wanted to conduct $3000 worth of tests which none of them included testing for asthma. We didn't do the expensive tests and he agreed to give us the inhaler. After a couple of treatments of the asthma inhaler, our cats asthma symptoms were gone. He stopped hacking immediately. We had to order the AeroKat which is a Feline Aerosol Chamber which allows you to administer the medicine (AeroKat.com). The medication is an inhaler called Fluticasone Propionate Ihalation IP 125 mcg/dose (Flohale Generic). We give him 2 to 3 puffs twice daily, 12 hours a part. The medicine we order is expensive in the United States so we have to order it from a Candian Pharmacy. We order from canadadrugsonline.com or call 877-900-3784 and get 6 months of medication for around $120. In the United States it would cost us about $80 a month. The AeroKat cost about $30 and we have been using the same one for 2 years now and it's still working great. I have learned a couple of things to help your cat with asthma attacks. 1st you <b>...</b>
0.80 min. | 4.61 user rating
www.genericforyou.com Advair Diskus (Fluticasone Salmeterol) is a combination medication. It is used as a long-term (maintenance) treatment to prevent or decrease wheezing and trouble breathing caused by asthma or ongoing lung disease (eg, COPD, emphysema). It works in the airways by decreasing swelling and relaxing muscles. Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Fluticasone and salmeterol inhalation is used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema Do not use fluticasone and salmeterol to treat an asthma attack that has already begun. Before using Advair Diskus (fluticasone and salmeterol), tell your doctor if you have a food or drug allergy, heart disease, high blood pressure, a seizure disorder, an infection, a weak immune system, diabetes, glaucoma, tuberculosis, osteoporosis, a thyroid disorder, or liver disease. Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. Salmeterol has been shown to increase the risk of asthma-related death. It is critical that you use only the prescribed dose of this medicine and follow all patient instructions for safe use of the medication. Do not use this medication if <b>...</b>
7.78 min. | 4.55 user rating
edit: Q_Q apparently Youtube gave me back my audio a year later LOLOLOL --------- a model test~ I made this video a few weeks ago but I finally got it to render~ ....had some minor difficulities. ^^ The model that looks like Neru is just a friend's edit named Reika. Don't mind it so much, guys credit: [model] Cyber Miku: fav.me Fluticasone: fav.me Reika: fav.me [motion] toot (sm12025860) [camera] 007mikoto (youtu.be I dot not own anything in this video.
4.28 min. | 4.91 user rating
A pharmacist explains how Advair Diskus works, why doctors prescribe this asthmatic treatment, and common side effects of the combination drug.Watch More Health Videos at Health Guru: www.healthguru.com
2.85 min. | 4.38 user rating
Courtesy of www.genericforyou.com Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Advair Diskus (Fluticasone and Salmeterol) inhalation is used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and emphysema.
1.02 min. | 5.0 user rating
DETAILS/INFORMATION: Music Artist: NantokaP / Kiichi Song: "Fluticasone" Vocals: Megurine Luka Illustration: www.zerochan.net MP3 Download [NicoSound]: nicosound.anyap.info None of the content within this video belongs to me.
3.72 min. | 5.0 user rating
Clip courtesy of www.genericforyou.com Advair Diskus (Fluticasone Salmeterol) is a combination medication. It is used as a long-term (maintenance) treatment to prevent or decrease wheezing and trouble breathing caused by asthma or ongoing lung disease (eg, COPD, emphysema). It works in the airways by decreasing swelling and relaxing muscles. Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Fluticasone and salmeterol inhalation is used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema Do not use fluticasone and salmeterol to treat an asthma attack that has already begun. Before using Advair Diskus (fluticasone and salmeterol), tell your doctor if you have a food or drug allergy, heart disease, high blood pressure, a seizure disorder, an infection, a weak immune system, diabetes, glaucoma, tuberculosis, osteoporosis, a thyroid disorder, or liver disease. Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. Salmeterol has been shown to increase the risk of asthma-related death. It is critical that you use only the prescribed dose of this medicine and follow all patient instructions for safe use of the medication. Do not use this <b>...</b>
1.10 min. | 0 user rating
Me dio curiosidad el titulo (ademas de que no entendia la letra ._.) y encontre algo que me ayudo un poquito a entender xD Lo pongo para las personas como yo, que no saben oo Fluticasone: La inhalación oral de fluticasona se usa para prevenir la dificultad para respirar, estrechez del pecho, resoplo (respiración con silbido inusual) y tos causada por el asma. La fluticasona pertenece a una clase de medicamentos llamados corticosteroides. Funciona al reducir la inflamación (hinchazón) y la irritación en las vías respiratorias para facilitar la respiración. Resumido... la cancion es sobre el asma o_o xD Video original: www.nicovideo.jp
3.50 min. | 4.82 user rating
None of this belongs to me but the translation~
3.45 min. | 4.85 user rating
Clip courtesy of www.genericforyou.com Advair Diskus (Fluticasone Salmeterol) is a combination medication. It is used as a long-term (maintenance) treatment to prevent or decrease wheezing and trouble breathing caused by asthma or ongoing lung disease (eg, COPD, emphysema). It works in the airways by decreasing swelling and relaxing muscles. Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Fluticasone and salmeterol inhalation is used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema Do not use fluticasone and salmeterol to treat an asthma attack that has already begun. Before using Advair Diskus (fluticasone and salmeterol), tell your doctor if you have a food or drug allergy, heart disease, high blood pressure, a seizure disorder, an infection, a weak immune system, diabetes, glaucoma, tuberculosis, osteoporosis, a thyroid disorder, or liver disease. Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. Salmeterol has been shown to increase the risk of asthma-related death. It is critical that you use only the prescribed dose of this medicine and follow all patient instructions for safe use of the medication. Do not use this <b>...</b>
2.20 min. | 5.0 user rating

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Association of Asthma With Clinically Aggressive Recurrent Respiratory ... - Archives of Otolaryngology Tweet this news
Archives of Otolaryngology--Fairfax AJ, David V, Douce G. Laryngeal aspergillosis following high dose inhaled -fluticasone- therapy for asthma. Thorax. 1999;54(9):860-861. FREE FULL TEXT 23. Krecicki T, Liebhart J, Morawska-Kochman M, Liebhart E, Zatoski - Date : Mon, 18 Apr 2011 20:10:43 GMT+00:00
Sunovion's Investigational Ciclesonide HFA Nasal Aerosol Effective In ... - Medical News Today (press release) Tweet this news
Medical News Today (press release)---...- Twice Daily in Subjects with Mild-to-Moderate Persistent Asthma Previously Receiving Low Dose -Fluticasone- Propionate/Salmeterol" on data pertaining to the inhaled corticosteroid (ICS) asthma therapy, AL - Date : Wed, 23 Mar 2011 13:11:07 GMT+00:00
No pneumonia risk from inhaled steroids - Pulse Tweet this news
Pulse--Similarly, there was no increased risk associated with budesonide when compared with -fluticasone-. Research lead Professor Paul O'Byrne, chair of medicine at McMaster University's faculty of health science, Ontario, said: 'Several r - Date : Thu, 07 Apr 2011 08:57:49 GMT+00:00
Spring Allergies and Liver Wellness - LiverSupport.com Tweet this news
LiverSupport.com--Nasal Steroid Sprays - A fairly effective way to treat allergic rhinitis, two examples of nasal steroid sprays are Flonase (-fluticasone-) and Nasonex (mometasone). Those with liver disease must discuss Flonase suitability and dosage wit - Date : Wed, 06 Apr 2011 16:28:32 GMT+00:00
Meda: Positive Study Results Presented For Dymista - Medical News Today (press release) Tweet this news
Medical News Today (press release)--Patients treated with Dymista experienced a 40 percent greater improvement in nasal symptoms, including congestion, relative to -fluticasone-. The mono substances (in the nasal antihistamine and corticosteroid markets r - Date : Wed, 23 Mar 2011 12:08:11 GMT+00:00
Positive study results presented for Dymista - PipelineReview.com (press release) Tweet this news
PipelineReview.com (press release)--Stockholm, SWEDEN | March 22, 2011 | Meda announced today positive results from a Phase III clinical trial of Dymista (also known as MP29-02), a novel formulation of azelastine hydrochloride and -fluticasone- propionate - Date : Tue, 22 Mar 2011 23:38:49 GMT+00:00
COPD Video: Tiotropium Most Effective at Preventing COPD Exacerbations - Insidermedicine Tweet this news
Insidermedicine--The first drug is called tiotropium or Spiriva and the second is called salmeterol or -Fluticasone-. Both drugs work by relaxing the smooth muscles in the lungs, but they do so by acting on different chemical pathways in the body. ... - Date : Thu, 24 Mar 2011 22:04:52 GMT+00:00
Spiriva viewed as most effective drug for COPD by US pulmonologists - The Pharma Letter Tweet this news
The Pharma Letter--Although GlaxoSmithKline's Advair/Seretide/Adoair (salmeterol/-fluticasone- propionate) was the COPD market sales leader in 2009, only 38% of surveyed pulmonologists selected it as the most efficacious therapy. Enjoying this articl - Date : Mon, 21 Mar 2011 09:57:38 GMT+00:00
New tiny nasal spray launched in battle to overcome annual hayfever misery - PRLog.Org (press release) Tweet this news
PRLog.Org (press release)---...- of the various treatment options showed Rhinolast Allergy to have a faster onset of action and better efficacy than the common steroid mometasone, while other research showed it to be as effective as the strongest corticos - Date : Thu, 24 Mar 2011 16:16:55 GMT+00:00
Prana shares jump on Alzheimer's data; Tesaro gains rights to Amgen's ALK tech; - FierceBiotech Tweet this news
FierceBiotech--Insmed release > Meda announced today positive results from a Phase III clinical trial of Dymista (also known as MP29-02), a novel formulation of azelastine hydrochloride and -fluticasone- propionate, in patients with seasonal allerg - Date : Tue, 22 Mar 2011 15:57:31 GMT+00:00

Decongestants and other nasal preparations (R01)

Topical
Sympathomimetics, plainCyclopentamine * Ephedrine * Phenylephrine * Oxymetazoline * Tetryzoline * Xylometazoline * Naphazoline * Tramazoline * Metizoline * Tuaminoheptane * Fenoxazoline * Tymazoline * Epinephrine
Antiallergic agents,
excluding corticosteroids
Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)
CorticosteroidsBeclometasone * Prednisolone * Dexamethasone * Flunisolide * Budesonide * Betamethasone * Tixocortol * Fluticasone * Mometasone furoate * Triamcinolone * Ciclesonide
Other nasal preparationsCafaminol * Calcium hexamine thiocyanate * Retinol * Ipratropium bromide * Ritiometan * Mupirocin * Hexamidine * Framycetin * Hyaluronic acid * Eucalyptus oil
Systemic use:
Sympathomimetics
Phenylpropanolamine * Pseudoephedrine * Phenylephrine * Phenylpropylamine |belowstyle=background:MistyRose

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants
Short acting &beta;2-agonistsSalbutamol/Levosalbutamol * Fenoterol * Terbutaline * Pirbuterol * Procaterol * Bitolterol * Rimiterol * Carbuterol * Tulobuterol * Reproterol
Long acting &beta;2-agonists (LABA)Arformoterol * Bambuterol * Clenbuterol * Formoterol * Salmeterol Ultra LABA: Indacaterol
otherEpinephrine * Hexoprenaline * Isoprenaline (Isoproterenol) * Orciprenaline (Metaproterenol)
Glucocorticoids
Beclometasone * Budesonide * Ciclesonide * Fluticasone * Mometasone
Anticholinergics/
muscarinic antagonist
Ipratropium * Tiotropium
Mast cell stabilizers
Cromoglicate * Nedocromil
Xanthines
Doxofylline * Theobromine * Theophylline/Aminophylline
Eicosanoid inhibition
Leukotriene antagonistsMontelukast * Pranlukast * Zafirlukast
Lipoxygenase inhibitorZileuton
Thromboxane receptor antagonistsRamatroban * Seratrodast
Combination products
Budesonide/formoterol * Fluticasone/salmeterol * Ipratropium/salbutamol |belowstyle=background:MistyRose

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |



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