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Fluocinolone acetonide

Fluocinolone acetonide
Drug information
Systematic (IUPAC) name
IUPAC name(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Chemical data
Mol. mass452.488 g/mol
MetabolismHepatic, CYP3A4-mediated
Half-life1.3 to 1.7 hours
Therapeutic considerations
Pregnancy cat C
RoutesTopical

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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01 � 0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. Category:Corticosteroids

Category:Organofluorides

Category:Otologicals



es:Acetónido de fluocinolona

fa:فلوئوسینولون

it:Fluocinolone acetonide

hu:Fluocinolon-acetonid

pl:Fluocynolon

ru:Синафлан









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Alimera resubmits NDA - ModernMedicine Tweet this news
ModernMedicine--Atlanta�Alimera Sciences Inc. resubmitted its new drug application, or NDA, for an investigational intravitreal insert containing -fluocinolone acetonide- (Iluvien) to the FDA May 12. This resubmission attempts to address the FDA's re - Date : Mon, 23 May 2011 22:08:14 GMT+00:00
Alimera Sciences resubmits new drug application - OSN SuperSite Tweet this news
OSN SuperSite--ATLANTA � Alimera Sciences has resubmitted a new drug application for -fluocinolone acetonide- implants to address a complete response letter from the US Food and Drug Administration, the company announced in a press release. ... - Date : Mon, 16 May 2011 15:29:05 GMT+00:00
pSivida Announces New Safety and Efficacy Data from Phase 3 Study of ILUVIEN ... - PharmaLive.com (press release) Tweet this news
PharmaLive.com (press release)---...- involving 956 patients in sites across the United States, Canada, Europe and India to assess the efficacy and safety of ILUVIEN with two doses of the corticosteroid -fluocinolone acetonide- (FAc), a high and low dose, - Date : Tue, 03 May 2011 13:58:20 GMT+00:00
Alimera's New 36-Month Safety and Efficacy Results From the Phase 3 Fame(TM ... - TradersHuddle.com (press release) Tweet this news
TradersHuddle.com (press release)---...- involving 956 patients in sites across the United States, Canada, Europe and India to assess the efficacy and safety of ILUVIEN with two doses of the corticosteroid -fluocinolone acetonide- (FAc), a high and low do - Date : Tue, 03 May 2011 13:28:32 GMT+00:00
Alimera Sciences Announces Upcoming Company Events - GlobeNewsWire (press release) Tweet this news
GlobeNewsWire (press release)--Its advanced product candidate, ILUVIEN®, is an intravitreal insert containing -fluocinolone acetonide-, a non-proprietary corticosteroid with demonstrated efficacy in the treatment of ocular disease. ILUVIEN® is an invest - Date : Tue, 26 Apr 2011 15:25:24 GMT+00:00
FAME results suggest steroid implant an efficacious treatment option for DME - OSN SuperSite Tweet this news
OSN SuperSite--Twenty-four month results for two phase 3 clinical trials suggested that low- and high-dose -fluocinolone acetonide- implants may be efficacious in treating diabetic macular edema, with the low-dose implant offering a superior risk-to-benef - Date : Fri, 29 Apr 2011 14:31:14 GMT+00:00
Alimera Sciences Inc (ALIM) Posts Large Volume Increase, Hits $7.05 - American Banking News Tweet this news
American Banking News--Iluvien is an intravitreal insert designed to provide a sustained therapeutic effect for up to 36 months by delivering a low daily dose of -fluocinolone acetonide- (FA), a corticosteroid with demonstrated efficacy in the treatment o - Date : Fri, 18 Mar 2011 19:04:18 GMT+00:00
Alimera Sciences to Hold Conference Call to Discuss Results From the Final ... - GlobeNewsWire (press release) Tweet this news
GlobeNewsWire (press release)--Its advanced product candidate, ILUVIEN®, is an intravitreal insert containing -fluocinolone acetonide-, a non-proprietary corticosteroid with demonstrated ... - Date : Thu, 27 Jan 2011 11:32:59 GMT+00:00
PSivida Announces $10.75 Million Registered Direct Financing - TheStreet.com (press release) (blog) Tweet this news
TheStreet.com (press release) (blog)--The Company's most advanced product candidate, Iluvien (R) , delivers -fluocinolone acetonide- (FA) for the treatment of diabetic macular edema. ... - Date : Thu, 20 Jan 2011 17:34:16 GMT+00:00
pSivida Completes Previously Announced Registered Direct Financing - PharmaLive.com (press release) Tweet this news
PharmaLive.com (press release)--The Company's most advanced product candidate, Iluvien (R) , delivers -fluocinolone acetonide- (FA) for the treatment of diabetic macular edema. ... - Date : Tue, 25 Jan 2011 19:06:54 GMT+00:00

Corticosteroids � glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE * 11-DEOXYCORTICOSTERONE * HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
PregneneCORTISONE
Pregnenedione
(+20-one)
HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) * Budesonide * Ciclesonide * Deflazacort * Medrysone * Tixocortol * HALOGENATED AT 6: Cloprednol * HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)Rimexolone * HALOGENATED, WITH FG AT 16: Flunisolide * Triamcinolone * Amcinonide * Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) * HALOGENATED AT 9: Fluorometholone * HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) * Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) * Desonide * HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) * HALOGENATED, WITH FG AT 16: Dexamethasone# * Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) * Beclometasone * Paramethasone * Alclometasone * Fluclorolone * Flumetasone * Fluprednidene
Pregnatriene
(+2-ene)
Cortivazol
AndrosteneHALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungroupedHALOGENATED: Loteprednol * HALOGENATED, WITH FG AT 16: Fludroxycortide * Formocortal * Mometasone furoate
Aldosterone antagonists
Spironolactone * Eplerenone * Potassium canrenoate * Canrenone
Synthesis
Trilostane * Carbenoxolone * Aminoglutethimide * Metyrapone |

Vasoprotectives (C05)

Antihemorrhoidals for topical usecorticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) other (Tribenoside)
Antivaricose therapyheparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) other (Calcium dobesilate)
Capillary stabilising agentsbioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

Otologicals (S02)

Anti-infectivesAcetic acid * Aluminium acetotartrate * Boric acid * Chloramphenicol * Chlorhexidine * Ciprofloxacin * Clioquinol * Gentamicin * Hydrogen peroxide * Miconazole * Neomycin * Nitrofurazone * Ofloxacin * Polymyxin B * Rifamycin * Tetracycline
CorticosteroidsBetamethasone * Dexamethasone * Fluocinolone acetonide * Hydrocortisone * Prednisolone
Analgesics and anestheticsLidocaine * Cocaine * Phenazone



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