Tetracaine : Ask Biography
AskBiography Logo   Latest News  Follow Us on Twitter  Follow Us on Google Buzz  Became Fan - Facebook  Subscribe to RSSRSS   Bookmark and Share

Tetracaine

Tetracaine
Drug information
Systematic (IUPAC) name
IUPAC name2-(dimethylamino)ethyl 4-(butylamino)benzoate
Chemical data
Mol. mass264.363 g/mol
Protein binding75.6
Therapeutic considerations
Legal status Rx Only
RoutesTopical, Epidural, Spinal

     Home | Drugs | Tetracaine



Tetracaine (INN, also known as amethocaine; trade name Pontocaine and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Tetracaine Video

Numfastâ„¢ Green Cream is a Universal Topical Anesthetic with a pH of 7.6. It is unique because it stays put and won't melt and run into the eye if applied on the eyelid(s). With an OTC strength of 2% Tetracaine it has a long lasting effect. Numfastâ„¢ Green comes in a hygienic " no waste" squeeze tube that lets you apply exactly what you want and just where you want it. Both safe and effective, Numfastâ„¢ can be used after the skin is slightly abraded as well.
2.63 min. | 2.86 user rating		 Creams, gels and ointments containing topical anesthetics such as lidocaine, tetracaine, benzocaine and prilocaine can be valuable in relieving or preventing pain. But they can be dangerous when used by patients without medical supervision. FDA is aware of two instances in which young women applied these preparations before laser hair removal. They wrapped the affected areas in plastic wrap to increase the numbing effect. Both women experienced seizures, became comatose and died. FDA has other reports of serious side effects from these anesthetic skin preparations, including cardiac arrhythmias, coma, and respiratory failure. If patients are considering medical or cosmetic skin procedures, advise them to consult a healthcare professional about whether a topical anesthetic is needed and, if so, how it can be safely used. Here are some recommendations for patients to consider: • First, patients should be advised to use a topical anesthetic approved by FDA. These can be found by searching for its name or active ingredient in FDA's Electronic Orange Book of Approved Drug Products. If it is not there, it may not be approved. • Patients should use a topical product that contains the lowest concentration of anesthetic drug that will satisfactorily relieve pain. They should apply as little of the product as possible, for the shortest possible time. • Patients should get instructions from a healthcare professional on how to safely use the product, particularly if there will not be <b>...</b>
2.22 min. | 3.66 user rating		 The IonFlux Instrument also facilitates other pharmacological experiments, including the example shown here typical for blockers of the neuronal hNav1.8 sodium channel, a voltage-gated channel involved in the perception of pain. In this assay, the Na+ channel, expressed in HEK293 cells was activated by voltage clamp steps from -120 mV to 0 mV, applied every second. This protocol therefore provides information on tonic block of the channel, since the channel re-enters the rested state between depolarizations. Cumulative blocker dose-response curves are illustrated for the local anesthetics lidocaine and tetracaine, providing IC50 values of 320 μM and 34 μM, respectively. In a second graph, the lidocaine affinity for hNaV1.8 is compared to that for hNaV1.7, another voltage-gated Na+ channel involved in pain sensation. The IC50 for hNaV 1.7 was found to be 3 mM, revealing a ten-fold lower affinity when this channel binds lidocaine, compared with hNaV1.8.
1.28 min. | 5.0 user rating		 Luke Walker gives a very enthusiastic informative speech on the many benefits of the tetraciane lollipop.
4.62 min. | 5.0 user rating

Latest News : Tetracaine : Tweet this RSS

Want to Tetracaine latest news on your twitter account???   sign in with twitter
Tetracaine     sign in with twitter   ||  Drugs     sign in with twitter   ||  Health     sign in with twitter
Need a new joint? Now you can grow your own - Daily Mail Tweet this news
Daily Mail--The patch contains a mix of painkillers, including lidocaine and -tetracaine-, and also has a heating element that helps the numbing medicine penetrate the skin. A clinical trial with 75 people is due to start at the US International Clinical - Date : Tue, 13 Mar 2012 00:24:54 GMT
Nuvo Research announces management change - MarketWatch (press release) Tweet this news
MarketWatch (press release)--Synera is a topical patch that combines lidocaine, -tetracaine- and heat, approved in the United States to provide local dermal analgesia for superficial venous access and superficial dermatological procedures and in Europe, f - Date : Mon, 09 Jan 2012 12:05:28 GMT
Advisory says use topical anesthetic with caution - Philippine Star Tweet this news
Philippine Star--In the 2007 alert, the FDA said that in two separate incidents, women in their 20s had seizures and went into comas after applying topical products that contained a high concentration of lidocaine and -tetracaine- to their legs and wrappi - Date : Sat, 12 Mar 2011 15:58:33 GMT+00:00

Vasoprotectives (C05)

Antihemorrhoidals for topical usecorticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) other (Tribenoside)
Antivaricose therapyheparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) other (Calcium dobesilate)
Capillary stabilising agentsbioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

Antipruritics (D04)

Antihistamines for topical useThonzylamine - Mepyramine - Thenalidine - Tripelennamine - Chloropyramine - Promethazine - Tolpropamine - Dimetindene - Clemastine - Bamipine - Isothipendyl - Diphenhydramine - Chlorphenoxamine
Anesthetics for topical useLidocaine - Cinchocaine - Oxybuprocaine - Benzocaine - Quinisocaine - Tetracaine - Pramocaine

Anesthetics: Local anesthetics - primarily sodium channel blockers (N01B)

Esters
Esters of aminobenzoic acidAmylocaine * Benzocaine * Butacaine * Butamben * Chloroprocaine * Dimethocaine * Meprylcaine * Metabutoxycaine * Orthocaine * Propoxycaine * Procaine (Novocaine) * Proxymetacaine * Risocaine * Tetracaine
Esters of benzoic acid3-(p-Fluorobenzoyloxy)tropane * Cocaine * Cyclomethycaine * Hexylcaine * Piperocaine
Amides
Articaine * Bupivacaine # /Levobupivacaine/Ropivacaine * Carticaine * Cinchocaine * Etidocaine * Lidocaine # * Mepivacaine * Prilocaine * Trimecaine |Combinations |Iontocaine * Lidocaine/prilocaine |belowstyle=background: LemonChiffon
Combinations
Iontocaine * Lidocaine/prilocaine |belowstyle=background: LemonChiffon



Privacy | Sitemap | Micra Hosting | USA Yellow Pages