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WIN 55,212-2 is a potent cannabinoid receptor agonist which has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling. WIN 55,212-2, alongside HU-210 and JWH-133, are implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models. WIN 55,212-2 is a full agonist at CB1 (Ki=1.9nM) and has much higher affinity than THC (Ki=41nM) for the CB1 receptor.. |