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Taranabant

Taranabant
Drug information
Systematic (IUPAC) name
IUPAC nameN-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- ((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide
Chemical data
FormulaC27H25Cl1F3N3O2
Mol. mass515.95
Therapeutic considerations
RoutesOral

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Taranabant (codenamed MK-0364) is a cannabinoid receptor type 1 inverse agonist being investigated as a potential treatment for obesity due to its anorectic effects. It was discovered by Merck & Co.

In October 2008, Merck has stopped its phase III clinical trials with the drugs due to high level of central side effects, mainly depression and anxiety.



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Antiobesity Agents/Anorectics (A08)

Central
Stimulants4-Methylamphetamine * Amfecloral * Amfepentorex * Amfepramone * Aminorex * Amphetamine * Amphetaminil * Atomoxetine * Benfluorex * Benzphetamine * Bupropion * Cathine * Cathinone * Chlorphentermine * Ciclazindol * Clobenzorex * Cloforex * Clominorex * Clortermine * Dexfenfluramine * Dextroamphetamine * Dextromethamphetamine * Dexmethylphenidate * Difemetorex * Dimethylcathinone * Diphemethoxidine * Ephedrine * Ephedra * Ethylamphetamine * Etolorex * Fenbutrazate * Fencamfamine * Fenethylline * Fenfluramine * Fenproporex * Fludorex * Fluminorex * Furfenorex * Indanorex * Khat * Levopropylhexedrine * Lisdexamfetamine * Manifaxine * Mazindol * Mefenorex * Methamphetamine * Methylphenidate * Pemoline * Pentorex (Phenpentermine) * Phendimetrazine * Phenethylamine * Phenmetrazine * Phentermine * Phenylpropanolamine * Pipradrol * Prolintane * Propylhexedrine * Pseudoephedrine * Pyrovalerone * Radafaxine * Reboxetine * Setazindol * Sibutramine * Synephrine * Tesofensine * Viloxazine * Xylopropamine * Zylofuramine
CannabinoidsIbipinabant * Otenabant * Rimonabant * Surinabant * Taranabant
Others5-HTP * Galactomannan (Guar Gum) * Glucomannan * L-DOPA * L-Phenylalanine * L-Tryptophan * L-Tyrosine * Lorcaserin * Lu AA-33810 * Metformin * Naltrexone * Naloxone * Oxyntomodulin * P57 * Peptide YY * Topiramate * Yohimbine (Yohimbe) * Zonisamide
Peripheral
Cetilistat * Dinitrophenol * Oleoyl-Estrone * Orlistat * Simmondsin * Sterculia

Cannabinoids

Plant cannabinoids
CBCV * CBD * CBDV * CBGM * CBGV * CBN * CBG * CBV * CBL * THC * THC-C4 * THCV |
Cannabinoid metabolites
8,11-DiOH-THC * 11-COOH-THC * 11-OH-THC |
Endogenous cannabinoids
Arachidonoyl ethanolamide (Anandamide or AEA) * 2-Arachidonoylglycerol (2-AG) * 2-Arachidonyl glyceryl ether (noladin ether) * Virodhamine * Palmitoylethanolamide (PEA) * N-Arachidonoyl dopamine (NADA) * Oleamide * RVD-Hpα |
Synthetic cannabinoid
receptor agonists
Classical cannabinoids
(Dibenzopyrans)
A-40174 * A-41988 * A-42574 * Ajulemic acid * AM-087 * AM-411 * AM-855 * AM-905 * AM-906 * AM-919 * AM-938 * AM-4030 * AMG-1 * AMG-3 * AMG-36 * AMG-41 * Dexanabinol (HU-211) * DMHP * Dronabinol * HHC * HU-210 * HU-243 * JWH-051 * JWH-133 * JWH-139 * JWH-229 * JWH-359 * L-759,633 * L-759,656 * Levonantradol (CP 50,5561) * Nabazenil * Nabidrox (Canbisol) * Nabilone * Nabitan * Naboctate * O-806 * O-823 * O-1057 * O-1125 * O-1238 * O-2545 * O-2694 * Parahexyl * Perrottetinene * Pirnabine * THC-O-acetate * THC-O-phosphate
Nonclassical cannabinoids CP 47,497 * CP 55,244 * CP 55,940 * HU-308 * Nonabine * SPA-229 * Tinabinol * 2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
Benzoylindoles AM-630 * AM-694 * AM-1241 * GW-405,833 (L-768,242) * Pravadoline
Naphthoylindoles AM-1220 * JWH-007 * JWH-015 * JWH-018 * JWH-019 * JWH-073 * JWH-081 * JWH-122 * JWH-182 * JWH-200 * JWH-210 * JWH-398 * WIN 55,212-2
Phenylacetylindoles JWH-203 * JWH-250 * JWH-251 * JWH-302
Naphthoylpyrroles JWH-030 * JWH-147 * JWH-307
Eicosanoids AM-883 * Arachidonyl-2'-chloroethylamide * Arachidonylcyclopropylamide * Methanandamide * O-585 * O-689 * O-1812 * O-1860 * O-1861
Others A-836,339 * Abnormal cannabidiol * BAY 38-7271 * BAY 59-3074 * CB-13 * GW-842,166X * JWH-171 * O-1918 * O-2220 * Leelamine * Org 28611 * VSN-16
Endocannabinoid
activity enhancers
AM-404 * CAY-10401 * CAY-10402 * JZL184 * N-arachidonoyl-serotonin * O-1624 * PF-622 * PF-750 * PF-3845 * URB-597 * URB-602 * Genistein * Arvanil * Olvanil * Kaempferol * Biochanin A * URB-754 |
Cannabinoid receptor
antagonists and
inverse agonists
AM-251 * AM-281 * AM-630 * BML-190 * CAY-10508 * CB-25 * CB-52 * Drinabant * Hemopressin * Ibipinabant * JTE-907 * LY-320,135 * MK-9470 * NESS-0327 * O-1184 * O-1248 * O-2050 * O-2654 * Org 27569 * Otenabant * Rimonabant * SR-144,528 * Surinabant * Taranabant * VCHSR |



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