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Surinabant

Drug information

Systematic (IUPAC) name
IUPAC name	5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl- N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
Chemical data
Formula	C₂₃H₂₃Br₁Cl₂N₄O₁
Mol. mass	522.264 g/mol

Home | Drugs | Surinabant

Surinabant (SR147778) is a cannabinoid receptor type 1 antagonist developed by Sanofi-Aventis. It is being investigated as a potential treatment for nicotine addiction, to assist smoking cessation. It may also be developed as an anorectic drug to assist with weight loss, however there are already several CB₁ antagonists or inverse agonists on the market or under development for this application, so surinabant is at present mainly being developed as an anti-smoking drug, with possible application in the treatment of other addictive disorders such as alcoholism. Other potential applications such as treatment of ADHD have also been proposed.

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Antiaddictives (N07B)

Nicotine dependence/ (Nicotinic agonist)		Nicotine * Dianicline * Varenicline * Lobeline * Mecamylamine * Scopolamine NDRI (Bupropion) * AA (Clonidine) * CB1 (Surinabant)
Alcohol dependence		AD inhibitor (Disulfiram, Calcium carbimide) * mGluR (Acamprosate) * Opioid receptor antagonists (Naltrexone, Nalmefene) * Topiramate * AA (Clonidine) * Baclofen
Opioid dependence		Buprenorphine * Methadone * Levacetylmethadol * Dihydrocodeine * Dihydroetorphine * AA (Clonidine) * Lofexidine * Extended Release Morphine * Extended Release Hydromorphone * Baclofen
Stimulant dependence		Dextroamphetamine * NDRI (Bupropion) * DRI (Vanoxerine) * Nocaine * GABA analogue (Vigabatrin)
Benzodiazepine dependence		AA (Clonidine) * benzodiazepine (Diazepam) * Phenytoin * barbiturate (Phenobarbital)
Cocaine dependence		NDRI (Bupropion) * DRI (Vanoxerine) * Nocaine * Baclofen * GABA analogue (Vigabatrin)
Sedative-Hypnotic dependence		barbiturate (Phenobarbital) * benzodiazepine (Diazepam, Lorazepam) * AA (Clonidine) * Chloral hydrate

Cannabinoids

Plant cannabinoids
CBCV * CBD * CBDV * CBGM * CBGV * CBN * CBG * CBV * CBL * THC * THC-C4 * THCV \|
Cannabinoid metabolites
8,11-DiOH-THC * 11-COOH-THC * 11-OH-THC \|
Endogenous cannabinoids
Arachidonoyl ethanolamide (Anandamide or AEA) * 2-Arachidonoylglycerol (2-AG) * 2-Arachidonyl glyceryl ether (noladin ether) * Virodhamine * Palmitoylethanolamide (PEA) * N-Arachidonoyl dopamine (NADA) * Oleamide * RVD-Hpα \|
Synthetic cannabinoid receptor agonists

Classical cannabinoids (Dibenzopyrans)		A-40174 * A-41988 * A-42574 * Ajulemic acid * AM-087 * AM-411 * AM-855 * AM-905 * AM-906 * AM-919 * AM-938 * AM-4030 * AMG-1 * AMG-3 * AMG-36 * AMG-41 * Dexanabinol (HU-211) * DMHP * Dronabinol * HHC * HU-210 * HU-243 * JWH-051 * JWH-133 * JWH-139 * JWH-229 * JWH-359 * L-759,633 * L-759,656 * Levonantradol (CP 50,5561) * Nabazenil * Nabidrox (Canbisol) * Nabilone * Nabitan * Naboctate * O-806 * O-823 * O-1057 * O-1125 * O-1238 * O-2545 * O-2694 * Parahexyl * Perrottetinene * Pirnabine * THC-O-acetate * THC-O-phosphate
Nonclassical cannabinoids		CP 47,497 * CP 55,244 * CP 55,940 * HU-308 * Nonabine * SPA-229 * Tinabinol * 2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
Benzoylindoles		AM-630 * AM-694 * AM-1241 * GW-405,833 (L-768,242) * Pravadoline
Naphthoylindoles		AM-1220 * JWH-007 * JWH-015 * JWH-018 * JWH-019 * JWH-073 * JWH-081 * JWH-122 * JWH-182 * JWH-200 * JWH-210 * JWH-398 * WIN 55,212-2
Phenylacetylindoles		JWH-203 * JWH-250 * JWH-251 * JWH-302
Naphthoylpyrroles		JWH-030 * JWH-147 * JWH-307
Eicosanoids		AM-883 * Arachidonyl-2'-chloroethylamide * Arachidonylcyclopropylamide * Methanandamide * O-585 * O-689 * O-1812 * O-1860 * O-1861
Others		A-836,339 * Abnormal cannabidiol * BAY 38-7271 * BAY 59-3074 * CB-13 * GW-842,166X * JWH-171 * O-1918 * O-2220 * Leelamine * Org 28611 * VSN-16
Endocannabinoid activity enhancers
AM-404 * CAY-10401 * CAY-10402 * JZL184 * N-arachidonoyl-serotonin * O-1624 * PF-622 * PF-750 * PF-3845 * URB-597 * URB-602 * Genistein * Arvanil * Olvanil * Kaempferol * Biochanin A * URB-754 \|
Cannabinoid receptor antagonists and inverse agonists
AM-251 * AM-281 * AM-630 * BML-190 * CAY-10508 * CB-25 * CB-52 * Drinabant * Hemopressin * Ibipinabant * JTE-907 * LY-320,135 * MK-9470 * NESS-0327 * O-1184 * O-1248 * O-2050 * O-2654 * Org 27569 * Otenabant * Rimonabant * SR-144,528 * Surinabant * Taranabant * VCHSR \|

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