Humphreys Peak was named in about 1870 for General Andrew A. Humphreys, a U.S. Army officer who was a Union general during the American Civil War, and who later became Chief of Engineers of the United States Army Corps of Engineers. However, a General Land Office map from 1903 showed the name San Francisco Peak applied to this feature (apparently borrowed from San Francisco Mountain on which the peak stands). Thus the United States Board on Geographic Names approved the variant name in 1911. In 1933, the application of the names was rectified.
The treeline of Humphreys Peak is around 11,400 ft. Hazards of the hike include a steep and rocky trail, risk of lightning strike, snow, and avalanche danger in winter.