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Heroin

Heroin
Drug information
Systematic (IUPAC) name
IUPAC name(5α,6α)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate
Chemical data
Mol. mass369.41 g/mol
SynonymsDiamorphine, Diacetylmorphine, Acetomorphine, (Dual) Acetylated morphine, Morphine diacetate
Bioavailability<35% (oral), 44 � 61% (inhaled)
Protein binding0% (morphine metabolite 35%)
Metabolismhepatic
Half-life<10 minutes
Excretion90% renal as glucuronides, rest biliary
Therapeutic considerations
Pregnancy cat Category X
Dependence LiabilityHigh
RoutesInhalation, Transmucosal, Intravenous, Oral, Intranasal, Rectal, Intramuscular

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Heroin (diacetylmorphine (INN)), also known as diamorphine (BAN), is a semi-synthetic opioid drug synthesized from morphine, a derivative of the opium poppy. It is the 3,6-diacetyl ester of morphine (di (two)-acetyl-morphine). The white crystalline form is commonly the hydrochloride salt diacetylmorphine hydrochloride, though often adulterated thus dulling the sheen and consistency from that to a matte white powder, which diacetylmorphine freebase typically is. 90% of diacetylmorphine is thought to be produced in Afghanistan.

As with other opioids, diacetylmorphine is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Internationally, diacetylmorphine is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs. It is illegal to manufacture, possess, or sell diacetylmorphine without a license in Belgium, Denmark, Germany, Iran, India, the Netherlands, the United States, Australia, Canada, Ireland, Pakistan, the United Kingdom and Swaziland.

Under the chemical name diamorphine, diacetylmorphine is a legally prescribed controlled drug in the United Kingdom. It is available for prescription to long-term users in the Netherlands, United Kingdom, Switzerland, Germany and Denmark alongside psycho-social care, and a similar programme is being campaigned for by liberal political parties in Norway. Some countries allow the government to sell or donate high-quality seizures of drugs and precursors which are otherwise legal for medicinal use to pharmaceutical manufacturers for use in preparing licit supplies of medical drugs and research chemicals; this was the case in Croatia prior to 2007.


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