Germ cell tumor
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A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or non-cancerous tumors. Germ cells normally occur inside the gonads (ovary and testis). Germ cell tumors that originate outside the gonads may be birth defects resulting from errors during development of the embryo.

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BCM pediatric cancer researchers get funding from St. Baldrick's Foundation - Media Newswire (press release) Tweet this news
Media Newswire (press release)--Terashima's fellowship focuses on intracranial -Germ Cell Tumors- ( GCT ), which are rare and poorly understood brain tumors that occur mostly in teenagers. ... - Date : Fri, 27 Aug 2010 14:19:49 GMT+00:00
Fertility among testicular cancer survivors: A case-control study in the U.S. ... - UroToday Tweet this news
UroToday--Testicular -germ cell tumors- (TGCT) disproportionately affect men between the ages of 15 and 49 years, when reproduction is typical. ... - Date : Mon, 02 Aug 2010 07:18:26 GMT+00:00
Cancer Biomarkers Missing in Action - Biomed Middle East Tweet this news
Biomed Middle East--“Notable exceptions,” he wrote, are human choriogonadotropin for -germ cell tumors- and gestational trophoblastic disease and α-fetoprotein for hepatocellular ... - Date : Fri, 13 Aug 2010 13:58:43 GMT+00:00
Pediatric germ cell tumor incidence increasing in certain subgroups - HemOncToday Tweet this news
HemOncToday--The incidence of -germ cell tumors- in certain pediatric populations has increased during the past few decades, especially in girls aged birth to 9 years and ... - Date : Thu, 08 Jul 2010 17:41:09 GMT+00:00
Testicular microlithiasis predicts concurrent testicular germ cell tumors and ... - UroToday Tweet this news
UroToday--There is an increasing body of literature associating testicular microlithiasis (TM), a common finding on testicular ultrasound, with testicular -germ cell- ... - Date : Mon, 05 Jul 2010 07:24:24 GMT+00:00
The incidence and management of metachronous testicular germ cell tumors in ... - UroToday Tweet this news
UroToday--The optimal management of extragonadal -germ cell tumor- (EGGCT) and metachronous testicular -germ cell tumor- (MTGCT) has not been determined. ... - Date : Mon, 28 Jun 2010 06:08:54 GMT+00:00
Full Text (HTML) - Securities Industry News (blog) (subscription) Tweet this news
Securities Industry News (blog) (subscription)---Cell- 128, 747 (2007). 2. P. Hajkova et al., Chromatin dynamics during epigenetic reprogramming in the mouse -germ- line. Nature 452, 877 (2008). 3. ... - Date : Thu, 01 Jul 2010 18:15:14 GMT+00:00
Health care reform is victory for ill son - Columbia Daily Tribune Tweet this news
Columbia Daily Tribune--That reason is my youngest son, who was diagnosed with a -germ cell- brain -tumor-. It was successfully removed in April, and the biopsy was positive for cancer ... - Date : Sun, 13 Jun 2010 13:09:39 GMT+00:00
Longtime assist. BB coach at Wapsie succumbs to cancer - Waterloo Cedar Falls Courier Tweet this news
Waterloo Cedar Falls Courier--He suffered from a -germ cell tumor- in his stomach. Risse, a Wapsie Valley alum, was an assistant basketball coach at Wapsie for nearly two decades. ... - Date : Tue, 01 Jun 2010 09:35:14 GMT+00:00
Toddle waddle's hoping to raise a wad for hospital ward - Wiltshire Times Tweet this news
Wiltshire Times--“I had intensive treatment there for three months about two years ago when I was diagnosed with a rare form of cancer called -germ cell- cancer. ... - Date : Sat, 19 Jun 2010 12:03:24 GMT+00:00

Germinomatous :
Tumor ICD-O Peak Age (yr) Benign or malignant Histology Tumor marker
Germinoma (including dysgerminoma and seminoma) 40-50 Malignant Sheets of uniform polygonal cells with cleared cytoplasm; lymphocytes in the stroma 10% have elevated hCG
Dysgerminoma  
Seminoma  

Nongerminomatous :
Tumor ICD-O Peak Age (yr) Benign or malignant Histology Tumor marker
Embryonal carcinoma 9070/3 20-30 Malignant Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation Pure tumors do not secrete hCG, AFP
Endodermal sinus tumor, also known as yolk sac tumor (EST, YST) 9071/3 3 Malignant Poorly differentiated endothelium-like, cuboidal, or columnar cells 100% secrete AFP
Choriocarcinoma 9100/3 20-30 Malignant Cytotrophoblast and syncytiotrophoblast without villus formation 100% secrete hCG
Teratoma including mature teratoma, dermoid cyst, immature teratoma, teratoma with malignant transformation 9080/0-9080/3 0-3, 15-30 Mature teratoma, dermoid cyst usually benign (but follow-up required); others usually malignant Very variable, but "normal" tissues are common Pure tumors do not secrete hCG, AFP
Polyembryoma 9072/3 15-25 ? ? ?
Gonadoblastoma 9073/1 ? ? ? ?

Mixed :
Tumor ICD-O Peak Age (yr) Benign or malignant Histology Tumor marker
Mixed 15-30 Malignant Depends on elements present Depends on elements present

Germ cell tumors (ICD-O 9060-9119) (C45-C49/D17-D21, 171/214-215)

GerminomatousGerminoma (Seminoma, Dysgerminoma)
NongerminomatousEmbryonal carcinoma Mesonephroma: Endodermal sinus tumor/Yolk sac tumor Teratoma: Fetus in fetu * Dermoid cyst * Struma ovarii Trophoblastic neoplasm: Gestational trophoblastic disease (Hydatidiform mole) * Choriocarcinoma * Placental site trophoblastic tumor Polyembryoma Gonadoblastoma

Tumors: female urogenital neoplasia * (C51-C58/D25-28, 179-184/218-221)

Adnexa

Tumors: female urogenital neoplasia * (C51-C58/D25-28, 179-184/218-221)

Adnexa
Adnexa
subgroup |groupstyle=background:#BBEEBB; |Ovaries |
Fallopian tube
Adenomatoid tumor

Tumors: male urogenital neoplasia * genital neoplasia (C60-C63/D29, 185-187/222)

Internal

Tumors: male urogenital neoplasia * genital neoplasia (C60-C63/D29, 185-187/222)

Internal
Internal
subgroup

Tumors: male urogenital neoplasia * genital neoplasia (C60-C63/D29, 185-187/222)

Internal
Internal
subgroup
Internal
subgroup |groupstyle=background-color: #BBEEBB; |Testicles |
Germ cell
GSeminoma (Spermatocytic seminoma) * Intratubular germ cell neoplasia
NGEmbryonal carcinoma * Endodermal sinus tumor * Gonadoblastoma * Teratoma * Choriocarcinoma * Embryoma



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