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Sildenafil

Sildenafil
Drug information
Systematic (IUPAC) name
IUPAC name1-[4-ethoxy-3-(6,7-dihydro-1-methyl-
7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)
phenylsulfonyl]-4-methylpiperazine
Chemical data
Mol. massbase: 474.6 g/mol
Bioavailability40%
MetabolismHepatic (mostly CYP3A4, also CYP2C9)
Half-life3 to 4 hours
ExcretionFecal (80%) and renal (around 13%)
Therapeutic considerations
Legal status Rx-only
RoutesOral

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Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra).

Sildenafil Video

We get our hands on a pure sample of Sildenafil citrate, known to many as Viagra, and discuss a few properties of this "blockbuster" drug. More chemistry at www.periodicvideos.com
5.43 min. | 4.93 user rating
Go to www.supavigrx.com and be the man you should be. She deserves it. VIAGRA Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction (male impotence) and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). CIALIS Tadalafil is an orally administered drug for treating impotence (erectile dysfunction), that initially was developed by the biotechnology company ICOS, and then developed and marketed world-wide as Cialis, by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 5mg, 10mg, and 20mg doses, are yellow, film-coated, and almond-shaped. In December 2003, the Food and Drug Administration approved tadalafil (as Cialis) for sale in the US as the third impotence prescription drug after sildenafil (Viagra) and vardenafil (Levitra). Cialis's 36-hour effectiveness earned it the nickname, "The Weekend Pill"; like sildenafil and vardenafil, tadalafil is recommended as a 'as needed' medication. Cialis is the only one of the three that is also offered as a once daily medication. Moreover, besides impotence <b>...</b>
1.20 min. | 1.0 user rating
Courtesy of www.medstores.net Viagra (Sildenafil Citrate)has revolutionized the way physicians treat men suffering from erectile dysfunction (ED). For the first time, a potent oral medication is available that is able to markedly improve sexual activity in over 80% of men with impotence. Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). Viagra relaxes muscles and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Viagra while also taking Revatio, unless your doctor tells you to. Viagra may also be used for other purposes.
0.25 min. | 5.0 user rating
More footage from Profesor Martyn Poliakoff on the drug Sildenafil citrate (Viagra) and why it is a triumph for green chemistry. Main video at www.youtube.com
3.37 min. | 4.96 user rating
This news report investigates about online pharmacies that sell the prescription drug, Viagra to anyone why orders it through the Internet. Doctors try to identify and shut down the many unlicensed Internet-based pharmacies, but the world is big. Most of Viagra suppliers online operate outside the United States, in countries where medical law enforcement is weak or can be compromised. What the video for more information. To learn more about authentic Viagra and find licensed online suppliers lease go to BuyViagraPillsOnline.com and get educated about the little blue pill before you get scammed by deceiving counterfeit drugs that are sold for "cheap". You can also compare genuine Viagra (sildenafil citrate tablets), Cialis (tadalafil) and Levitra (Vardenafil) sold online on the following page: BuyViagraPillsOnline.com Remember to never take any medication you buy online before talking to a doctor.
2.97 min. | 4.33 user rating
BuyAuthenticViagra.com Viagra is the #1 prescription medication for erectile dysfunction. Many men use Viagra pills to get hard and lasting erections during sexual activity. The Internet is full of Viagra discount offers but most of those pills are fake! Prescription drugs are...
1.03 min. | 0 user rating
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Tagazepin de Menta ( sildenafil comprimidos masticables )
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Curta-metragem dirigido por Clovis Mello e produzido pela Cine Cinematográfica www.cine.com.br
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Live from castelmassa 21 May 2005
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Medications used in the management of pulmonary arterial hypertension (B01, C02)

Prostacyclin analoguesBeraprost, Epoprostenol, Iloprost, Treprostinil
Endothelin receptor antagonistsAmbrisentan, Bosentan, Sitaxentan
PDE5 inhibitorsSildenafil, Tadalafil
Statins--> Simvastatin-->
Adjunctive therapyCalcium channel blockers, Diuretics, Digoxin, Oxygen therapy, Warfarin

Phosphodiesterase inhibitors (C01CE, G04BE)

PDE1MMPX * SCH-51866 * Vinpocetine
PDE2BAY 60-7550 * EHNA
PDE3Amrinone * Anagrelide * Bucladesine * Cilostamide * Cilostazol * Enoximone * KMUP-1 * Milrinone * Quazinone * RPL-554 * Siguazodan * Trequinsin * Vesnarinone * Zardaverine
PDE4Arofylline * Cilomilast * CP-80633 * Denbutylline * Drotaverine * Etazolate * Filaminast * Glaucine * HT-0712 * Ibudilast * ICI-63197 * Irsogladine * Mesembrine * Pentoxifylline * Propentofylline * Roflumilast * Rolipram * Ro20-1724 * RPL-554 * YM-976
PDE5Acetildenafil * Avanafil * Dipyridamole * Icariin * Lodenafil * Mirodenafil * MY-5445 * Sildenafil * T-0156 * Tadalafil * Thiomethisosildenafil * Udenafil * Vardenafil
PDE6Zaprinast
PDE7BRL-50481
PDE8
PDE9BAY 73-6691 * SCH-51866
PDE10Papaverine * PF-2545920 * Tofisopam
PDE11
NonselectiveCaffeine * Theophylline * IBMX * Doxofylline
Unknown/ungrouped

Piperazines

Simple piperazines
(no additional rings)
1-Cyclohexylpiperazine * Aminoethylpiperazine * Diethylcarbamazine * HEPPS * Midafotel * Piperazine * PIPES
PhenylpiperazinesAcaprazine * Antrafenine * Aripiprazole * Batoprazine * Bifeprunox * BRL-15,572 * Ciprofloxacin * Dapiprazole * DCPP * DMPP * Dropropizine * EGIS-12,233 * Elopiprazole * Eltoprazine * Enpiprazole * Ensaculin * Etoperidone * Flesinoxan * Flibanserin * Fluprazine * Itraconazole * Ketoconazole * Levodropropizine * Lorpiprazole * mCPP * MeOPP * Mepiprazole * Naftopidil * Naphthylpiperazine * Nefazodone * Niaprazine * Oxypertine * Pardoprunox * pCPP * pFPP * Posaconazole * PRX-00023 * S-15,535 * SB-258,585 * SB-271,046 * SB-357,134 * SB-399,885 * Sonepiprazole * TFMPP * Tolpiprazole * Trazodone * Urapidil * Vesnarinone * Vilazodone * WAY-100,135 * WAY-100,635
Benzylpiperazines2C-B-BZP * Befuraline * Bifeprunox * Buclizine * BZP * Chlorbenzoxamine * DBZP * Fipexide * Imatinib * MBZP * MDBZP * Meclizine * Piberaline * Piribedil * Trimetazidine * Vesnarinone
Diphenylalkylpiperazines
(benzhydrylalkylpiperazines)
Almitrine * Amperozide * BRL-15,572 * Buclizine * BW373U86 * Cetirizine * Chlorbenzoxamine * Chlorcyclizine * Cinnarizine * Clocinizine * Cyclizine * DBL-583 * Diphenylmethylpiperazine * Dotarizine * DPI-221 * DPI-287 * DPI-3290 * GBR-12,783 * GBR-12,935 * GBR-13,069 * GBR-13,098 * GBR-13,119 * Hydroxyzine * Lidoflazine * Manidipine * Meclizine * Oxatomide * SNC-80 * Vanoxerine
PyrimidinylpiperazinesBuspirone * Dasatinib * Eptapirone * Gepirone * Ipsapirone * Piribedil * Pyrimidinylpiperazine * Revospirone * Tandospirone * Tirilazad * Trimazosin * Umespirone * Zalospirone
PyridinylpiperazinesAtevirdine * Azaperone * Pyridinylpiperazine
Benzo(iso)thiazolylpiperazinesLurasidone * Perospirone * Revospirone * Tiospirone * Ziprasidone
Tricyclics
(piperazine attached via side chain)
Amoxapine * Clopenthixol * Clozapine * Flupentixol * Fluphenazine * Loxapine * Olanzapine * Opipramol * Perazine * Perphenazine * Pirenzepine * Prochlorperazine * Thiethylperazine * Thiothixene * Trifluoperazine * Zuclopenthixol
Others6-Nitroquipazine * Azimilide * Cinepazet * Cyclohexylpiperazine * Hexocyclium * Indinavir * JNJ-7777120 * Lodenafil * Mirodenafil * PB-28 * Quipazine * Ranolazine * SA-4503 * Sildenafil * Tadalafil * Vardenafil * VUF-6002 * Zipeprol



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