Infante made his professional debut in 1942 for Estudiantes, he scored his first goal for the club on 1 August 1943 in a 2-2 draw with Chacarita Juniors. Infante went on to score 180 goals for the club in 328 games.
One of Infante's greatest moments came on 19 September 1948 in a game against Rosario Central, with Estudiantes already winning 2-0 Infante scored a goal with a right-footed rabona from 35 metres out.
Infante left the club in 1953 after their relegation from the Primera, he joined Club Atlético Huracán where he played until 1956. He then returned to Estudiantes for a second spell with the club.
In 1958 Infante was part of the Argentina squad that played in the 1958 FIFA World Cup.
In 1960 Estudiantes refused to renew his contract after he suffered a knee injury, prompting him to join fierce local rivals Gimnasia de La Plata. He retired later that year and went on to work as a youth coach in La Plata.
Infante currently occupies 6th place on the list of the Primera División Argentina all-time topscorers with 217 goals in 439 games.