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Isabella of Portugal (24 October 1503 � 1 May 1539) was a Portuguese Princess (Infanta) and Holy Roman Empress, Duchess of Burgundy, and a Queen Regent/Consort of Spain. She was the daughter of Manuel I of Portugal and Maria of Aragon. By her marriage to Charles V, Holy Roman Emperor, Isabella was also Holy Roman Empress and Queen consort of Aragon and Castile. She served as the regent of Spain during the absence of her spouse for long periods. |