The legendary cattle baron Charles Goodnight spent his later years in Donley County. It was also the home of historian Harley True Burton, author of A History of the JA Ranch, which Goodnight formerly co-owned. Burton was president of Clarendon College and the mayor of Clarendon from 1955-1963. The JA Ranch is located in the counties of Donley, Hall, Briscoe, and Armstrong.
Donley County is also the home of Republican U.S. Representative Mac Thornberry.
Aviation historian Randy Acord (1919-2008) was originally from Donley County.
The Harold Dow Bugbee Ranch, formerly owned by the Western artist and his second wife, Olive Vandruff Bugbee, also an artist, is located in Donley County.
On U.S. Highway 287, which runs through the county, there is a modern rest area with free wi-fi.
See also: Saints' Roost Museum in Clarendon.