Cape Girardeau County is a county located in Southeast Missouri in the United States. As of the 2000 U.S. Census, the county's population was 68,693; a 2008 estimate, however, showed the population to be 73,243. While the largest city in the county is Cape Girardeau, the county seat is actually Jackson, which was the first city named in honor of President Andrew Jackson . The county was officially organized on October 1, 1812.
Cape Girardeau County is the central hub of the Cape Girardeau - Jackson, MO-IL Metropolitan Statistical Area.
The county is the site of the oldest cold case in the state of Missouri. Bonnie Huffman, a 20-year-old schoolteacher, was found murdered in a ditch just outside of Delta on July 2, 1954.
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